BAD, BCL2 associated agonist of cell death

BAD, BCL2 associated agonist of cell death

• The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]

• Gene Synonyms (bcl2-associated agonist of cell death, BCL-X/BCL-2 binding protein, BCL2-antagonist of cell death protein, BCL2-binding component 6, BCL2-binding protein, bcl-2-binding component 6, bcl-2-like protein 8, bcl-XL/Bcl-2-associated death promoter, bcl2 antagonist of cell death, bcl2-L-8, BBC2, BCL2L8,)
• NCBI Gene ID: 572
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R562
  UNIPROT ID#>>Q92934
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 associated agonist of cell death interacts with:

• aprataxin
  BCL2 apoptosis regulator
  BCL2 associated X, apoptosis regulator
  BCL2 like 1
  BCL2 like 10
  BCL2 like 2
  BCL2 related protein A1
  beclin 1
  B-Raf proto-oncogene, serine/threonine kinase
  breast cancer 1, early onset
  cAMP responsive element binding protein 3 like 3
  chibby family member 1, beta catenin antagonist
  cyclin dependent kinase inhibitor 1A
  EWS RNA binding protein 1
  GTPase, IMAP family member 5
  harakiri, BCL2 interacting protein
  heterogeneous nuclear ribonucleoprotein L
  kelch like ECH associated protein 1
  keratin 31
  LIM domain kinase 1
  MCL1 apoptosis regulator, BCL2 family member
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase 5
  NADH:ubiquinone oxidoreductase subunit A12
  p21 (RAC1) activated kinase 1
  p21 (RAC1) activated kinase 5
  peroxiredoxin 2
  Pim-1 proto-oncogene, serine/threonine kinase
  Pim-2 proto-oncogene, serine/threonine kinase
  Pim-3 proto-oncogene, serine/threonine kinase
  protein kinase C epsilon
  protein kinase C iota
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase D1
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit alpha
  Raf-1 proto-oncogene, serine/threonine kinase
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A2
  ribosomal protein S6 kinase A3
  ribosomal protein S6 kinase A5
  S100 calcium binding protein A10
  small ubiquitin like modifier 2
  sortilin 1
  STEAP3 metalloreductase
  stratifin
  synaptotagmin binding cytoplasmic RNA interacting protein
  synuclein alpha
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  unc-51 like autophagy activating kinase 1
  valosin containing protein
  WASP family member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.