BIN1, bridging integrator 1

BIN1, bridging integrator 1

• This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]

• Gene Synonyms (myc box-dependent-interacting protein 1, amphiphysin II, amphiphysin-like protein, box dependant MYC interacting protein 1, box-dependent myc-interacting protein 1, AMPH2, AMPHL, CNM2, SH3P9,)
• NCBI Gene ID: 274
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RAI6
  UNIPROT ID#>>A0A024RAF0
  UNIPROT ID#>>A0A024RAG9
  UNIPROT ID#>>A0A024RAI4
  UNIPROT ID#>>A0A024RAF1
  UNIPROT ID#>>A0A024RAG8
  UNIPROT ID#>>A0A024RAJ3
  UNIPROT ID#>>A0A024RAF6
  UNIPROT ID#>>B7Z2Z2
  UNIPROT ID#>>O00499
  UNIPROT ID#>>A0A024RAJ2
  UNIPROT ID#>>A0A024RAE9
  UNIPROT ID#>>Q9BTH3
  UNIPROT ID#>>B7Z6Y2
  UNIPROT ID#>>A0A024RAI5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

bridging integrator 1 interacts with:

• amyloid beta precursor protein
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  ataxin 2
  beclin 1
  bridging integrator 1
  bridging integrator 2
  calmodulin 1
  CAP-Gly domain containing linker protein 1
  charged multivesicular body protein 4B
  clathrin heavy chain
  clusterin
  cut like homeobox 1
  deoxyguanosine kinase
  DLG associated protein 4
  dynamin 1
  dynamin 2
  E2F transcription factor 1
  EH domain binding protein 1 like 1
  EH domain binding protein 1-like 1
  ELAV like RNA binding protein 1
  enolase 1
  Fc fragment of IgG receptor IIa
  Fc fragment of IgG receptor IIIa
  four and a half LIM domains 2
  fructose-bisphosphatase 1
  histone deacetylase 6
  hypoxia up-regulated 1
  importin 8
  insulin receptor substrate 4
  integrin subunit alpha 1
  integrin subunit alpha 3
  integrin subunit alpha 6
  itchy E3 ubiquitin protein ligase
  Kruppel like factor 8
  microtubule associated protein tau
  mitogen-activated protein kinase kinase kinase kinase 3
  Mov10 RISC complex RNA helicase
  muscleblind like splicing regulator 1
  MYC proto-oncogene, bHLH transcription factor
  myotubularin 1
  non-SMC condensin II complex subunit D3
  nuclear FMR1 interacting protein 1
  nuclear RNA export factor 1
  phosphodiesterase 4D
  phospholipase D1
  phospholipase D2
  protein tyrosine kinase 2
  RAB8A, member RAS oncogene family
  RAB8B, member RAS oncogene family
  RAP1A, member of RAS oncogene family
  Ras and Rab interactor 2
  Ras and Rab interactor 3
  regulatory factor X3
  RNA binding motif protein 12
  RNA polymerase II subunit M
  serine hydroxymethyltransferase 2
  SH3 domain containing GRB2 like 2, endophilin A1
  SH3 domain containing GRB2 like, endophilin B1
  sorting nexin 4
  SOS Ras/Rac guanine nucleotide exchange factor 1
  SOS Ras/Rho guanine nucleotide exchange factor 2
  spectrin repeat containing nuclear envelope protein 2
  synapsin I
  synaptojanin 1
  tripartite motif containing 25
  tumor protein p73
  tyrosine kinase non receptor 2
  ubiquitin C
  VPS18 core subunit of CORVET and HOPS complexes
  WASP like actin nucleation promoting factor
  WASP like actin nucleation promoting factor
  X-ray repair complementing defective repair in Chinese hamster cells 5
  X-ray repair complementing defective repair in Chinese hamster cells 6
  X-ray repair cross complementing 4
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  zinc finger and BTB domain containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.