AP2B1, adaptor related protein complex 2 subunit beta 1

AP2B1, adaptor related protein complex 2 subunit beta 1

• The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ADTB2, AP105B, AP2-BETA, CLAPB1, AP-2 complex subunit beta, adapter-related protein complex 2 beta subunit, adapter-related protein complex 2 subunit beta, adaptin, beta 2 (beta), adaptor protein complex AP-2 subunit beta, adaptor related protein complex 2 beta 1 subunit, adaptor-related protein complex 2 subunit beta, beta-2-adaptin, beta-adaptin, clathrin assembly protein complex 2 beta large chain, clathrin-associated/assembly/adaptor protein, large, beta 1, plasma membrane adaptor HA2/AP2 adaptin beta subunit, testicular tissue protein Li 22,)
• NCBI Gene ID: 163
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJE8
  UNIPROT ID#>>P63010
  UNIPROT ID#>>Q96EL6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adaptor related protein complex 2 subunit beta 1 interacts with:

• actin, beta
  adaptor related protein complex 1 subunit gamma 1
  adaptor related protein complex 1 subunit mu 1
  adaptor related protein complex 1 subunit mu 2
  adaptor related protein complex 1 subunit sigma 1
  adaptor related protein complex 1 subunit sigma 2
  adaptor related protein complex 2 subunit mu 1
  adaptor related protein complex 2 subunit sigma 1
  ADP ribosylation factor GTPase activating protein 1
  AF4/FMR2 family member 4
  AKT serine/threonine kinase 3
  amphiphysin
  anillin actin binding protein
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  AP2 associated kinase 1
  APC regulator of WNT signaling pathway
  argonaute RISC catalytic component 2
  arrestin beta 1
  arrestin beta 2
  ATM serine/threonine kinase
  ATP23 metallopeptidase and ATP synthase assembly factor homolog
  ATPase H+ transporting V1 subunit G1
  autophagy related 16 like 1
  bone morphogenetic protein receptor type 1A
  B-Raf proto-oncogene, serine/threonine kinase
  BRCA1 DNA repair associated
  bromodomain containing 7
  BTB domain containing 8
  BUB1 mitotic checkpoint serine/threonine kinase
  BUB1 mitotic checkpoint serine/threonine kinase B
  C2 calcium dependent domain containing 6
  calcium binding protein 39
  calmodulin-like 3
  centrosomal protein 128
  clathrin heavy chain
  clathrin interactor 1
  clathrin light chain B
  coiled-coil domain containing 187
  collagen type III alpha 1 chain
  CRK proto-oncogene, adaptor protein
  crystallin lambda 1
  cullin 3
  cyclin G associated kinase
  CYLD lysine 63 deubiquitinase
  cytochrome c oxidase subunit 5B
  DAB adaptor protein 2
  DExH-box helicase 58
  dishevelled segment polarity protein 2
  DnaJ heat shock protein family (Hsp40) member C5
  DnaJ heat shock protein family (Hsp40) member C6
  drebrin 1
  dual specificity tyrosine phosphorylation regulated kinase 1A
  elongation factor Tu GTP binding domain containing 2
  enhancer of mRNA decapping 4
  EPH receptor A2
  epidermal growth factor receptor
  epidermal growth factor receptor pathway substrate 15
  epsin 1
  erb-b2 receptor tyrosine kinase 2
  estrogen receptor 2
  exportin 1
  exportin 7
  fibronectin 1
  filamin A
  filamin, beta
  formin like 2
  G2 and S-phase expressed 1
  general transcription factor IIi
  glycogen synthase kinase 3 beta
  G-patch domain and ankyrin repeats 1
  growth factor receptor bound protein 2
  H2A clustered histone 4
  heat shock protein family B (small) member 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 2
  huntingtin
  huntingtin interacting protein 1
  integrin alpha 5 (fibronectin receptor alpha)
  integrin subunit alpha 4
  intersectin 1
  karyopherin subunit alpha 2
  KIAA0408
  kinesin family binding protein
  KN motif and ankyrin repeat domains 2
  leucyl and cystinyl aminopeptidase
  leucyl-tRNA synthetase 1
  LIM domain and actin binding 1
  LON peptidase N-terminal domain and ring finger 1
  low density lipoprotein receptor adaptor protein 1
  male-enhanced antigen 1
  mex-3 RNA binding family member C
  microtubule associated protein 1 light chain 3 alpha
  mindbomb E3 ubiquitin protein ligase 1
  minichromosome maintenance complex component 2
  MMS19 homolog, cytosolic iron-sulfur assembly component
  mutL homolog 1
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myosin VI
  myosin XIX
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  myotubularin related protein 4
  NECAP endocytosis associated 2
  neuraminidase 4
  neurotrophic receptor tyrosine kinase 1
  nucleolar and spindle associated protein 1
  nucleoporin 50
  nucleoporin 54
  NUMB endocytic adaptor protein
  OCRL inositol polyphosphate-5-phosphatase
  outer dense fiber of sperm tails 2
  oxysterol binding protein like 10
  phosphatidylinositol binding clathrin assembly protein
  phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
  pleckstrin homology domain containing A4
  POM121 transmembrane nucleoporin
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  protein phosphatase 6 catalytic subunit
  psoriasis susceptibility 1 candidate 2
  Rap guanine nucleotide exchange factor 3
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  RIB43A domain with coiled-coils 2
  ring finger 111
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 11
  RNA binding protein with serine rich domain 1
  RUN domain containing 3A
  SEC24 homolog C, COPII coat complex component
  Sec24 related gene family, member C (S. cerevisiae)
  sequestosome 1
  SHC adaptor protein 1
  sirtuin 7
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 1
  solute carrier family 2 member 8
  solute carrier family 25 member 6
  sorting nexin 9
  synaptosome associated protein 91
  TERF2 interacting protein
  terminal nucleotidyltransferase 5C
  testis expressed 12
  THAP domain containing 1
  thioredoxin 2
  thymopoietin
  transcription factor AP-2 alpha
  transferrin receptor
  transforming growth factor beta receptor 1
  transforming growth factor beta receptor 2
  trans-golgi network protein 2
  translocase of outer mitochondrial membrane 40
  tripartite motif containing 25
  tropomyosin 1, alpha
  tubulin gamma complex associated protein 4
  tumor necrosis factor
  tumor protein p53
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 1 like 5
  ubiquitin C
  USO1 vesicle docking factor
  UTP25 small subunit processor component
  valosin containing protein
  VAMP associated protein A
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.