CCR5, C-C motif chemokine receptor 5

CCR5, C-C motif chemokine receptor 5

• This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

• Gene Synonyms (C-C chemokine receptor type 5, C-C motif chemokine receptor 5 A159A, HIV-1 fusion coreceptor, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemokine recptor CCR5 Delta32, chemr13, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22,)
• NCBI Gene ID: 1234
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51681
  UNIPROT ID#>>Q38L21
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine receptor 5 interacts with:

• ADP ribosylation factor like GTPase 6 interacting protein 5
  C-C motif chemokine ligand 11
  C-C motif chemokine ligand 13
  C-C motif chemokine ligand 14
  C-C motif chemokine ligand 16
  C-C motif chemokine ligand 2
  C-C motif chemokine ligand 3
  C-C motif chemokine ligand 3 like 1
  C-C motif chemokine ligand 3 like 3
  C-C motif chemokine ligand 4
  C-C motif chemokine ligand 5
  C-C motif chemokine ligand 7
  C-C motif chemokine ligand 8
  C-C motif chemokine receptor 2
  C-C motif chemokine receptor 5
  C-terminal binding protein 2
  C-X-C motif chemokine receptor 4
  cystatin 9 like
  dynamin 2
  epithelial membrane protein 1
  ETS variant transcription factor 5
  G protein subunit alpha i1
  G protein subunit alpha i2
  G protein subunit alpha i3
  G protein subunit alpha o1
  G protein subunit alpha q
  interleukin 24
  Janus kinase 1
  Janus kinase 2
  LCK proto-oncogene, Src family tyrosine kinase
  orosomucoid 1
  phosphoinositide-3-kinase regulatory subunit 2
  PRA1 domain family member 2
  proteasome 20S subunit alpha 5
  protein tyrosine kinase 2
  protein tyrosine kinase 2 beta
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  TXK tyrosine kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.