GRK3, G protein-coupled receptor kinase 3

GRK3, G protein-coupled receptor kinase 3

• The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ADRBK2, BARK2, beta-adrenergic receptor kinase 2, adrenergic, beta, receptor kinase 2, beta-ARK-2,)
• NCBI Gene ID: 157
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R1D8
  UNIPROT ID#>>P35626
  UNIPROT ID#>>Q8N433
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

G protein-coupled receptor kinase 3 interacts with:

• angiotensin II receptor type 1
  bradykinin receptor B2
  C-C motif chemokine receptor 4
  C-C motif chemokine receptor 5
  C-X-C motif chemokine receptor 4
  GIT ArfGAP 1
  heat shock protein family B (small) member 1
  heterogeneous nuclear ribonucleoprotein L
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  opioid receptor mu 1
  patched 1
  SMAD specific E3 ubiquitin protein ligase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.