BDKRB2, bradykinin receptor B2

BDKRB2, bradykinin receptor B2

• This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]

• Gene Synonyms (B2 bradykinin receptor, BK-2 receptor, B2R, BK-2, BK2, BKR2, BRB2,)
• NCBI Gene ID: 624
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30411
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

bradykinin receptor B2 interacts with:

• angiotensin I converting enzyme
  BAG cochaperone 3
  G protein subunit alpha 11
  G protein-coupled receptor kinase 4
  G protein-coupled receptor kinase 5
  G protein-coupled receptor kinase 6
  nitric oxide synthase 1
  nitric oxide synthase 3
  protein kinase C delta
  protein tyrosine phosphatase non-receptor type 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.