GRK2, G protein-coupled receptor kinase 2

GRK2, G protein-coupled receptor kinase 2

• This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]

• Gene Synonyms (ADRBK1, BARK1, BETA-ARK1, beta-adrenergic receptor kinase 1, adrenergic beta receptor kinase 1, beta-ARK-1,)
• NCBI Gene ID: 156
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z392
  UNIPROT ID#>>P25098
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

G protein-coupled receptor kinase 2 interacts with:

• A-kinase anchoring protein 12
  aminolevulinate dehydratase
  angiotensin II receptor type 1
  arrestin beta 1
  arrestin beta 2
  asparaginyl-tRNA synthetase 2, mitochondrial
  BICD cargo adaptor 1
  BICD cargo adaptor 2
  bradykinin receptor B2
  calpain 2
  casein kinase 2 beta
  caveolin 1
  C-C motif chemokine receptor 4
  C-C motif chemokine receptor 5
  CTR9 homolog, Paf1/RNA polymerase II complex component
  DEAD-box helicase 6
  dynein axonemal assembly factor 5
  endothelin receptor type B
  EPH receptor A2
  epidermal growth factor
  epidermal growth factor receptor
  erb-b2 receptor tyrosine kinase 2
  F-box protein 25
  fermitin family member 2
  follicle stimulating hormone receptor
  formyl peptide receptor 1
  G protein subunit alpha 15
  G protein subunit alpha q
  G protein subunit beta 1
  G protein subunit beta 2
  G protein subunit beta 3
  G protein-coupled receptor 17
  G protein-coupled receptor kinase 3
  GIT ArfGAP 1
  GIT ArfGAP 2
  glutamate metabotropic receptor 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  histone deacetylase 6
  kinesin family member 13B
  mannan binding lectin serine peptidase 2
  MDM2 proto-oncogene
  melanocortin 4 receptor
  mitogen-activated protein kinase 3
  Mov10 RISC complex RNA helicase
  neuronal calcium sensor 1
  opioid receptor delta 1
  patched 1
  peptidylprolyl isomerase domain and WD repeat containing 1
  phosducin
  phosducin like
  phosphatidylethanolamine binding protein 1
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  phosphodiesterase 6G
  phospholipase C beta 1
  platelet derived growth factor receptor beta
  poly(A) polymerase alpha
  potassium voltage-gated channel interacting protein 3
  pre-mRNA processing factor 4
  protein kinase C alpha
  protein kinase C beta
  protein kinase C delta
  protein kinase C gamma
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 16B
  protein tyrosine phosphatase receptor type F
  protein tyrosine phosphatase receptor type J
  pyridoxal phosphate binding protein
  Rap guanine nucleotide exchange factor (GEF) 3
  Ras protein specific guanine nucleotide releasing factor 1
  recoverin
  regulatory factor X, 5 (influences HLA class II expression)
  retinoid X receptor beta
  rhodopsin
  ribosomal protein lateral stalk subunit P2
  SLAIN motif family member 2
  smoothened, frizzled class receptor
  SRC proto-oncogene, non-receptor tyrosine kinase
  synuclein alpha
  TBC1 domain family member 14
  transportin 1
  tropomyosin 2
  vitamin D receptor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.