PARP1, poly(ADP-ribose) polymerase 1

PARP1, poly(ADP-ribose) polymerase 1

• This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADP-ribosyltransferase NAD(+), ADP-ribosyltransferase diphtheria toxin-like 1, DNA ADP-ribosyltransferase PARP1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthase 1, protein poly-ADP-ribosyltransferase PARP1,)
• NCBI Gene ID: 142
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09874
  UNIPROT ID#>>A0A024R3T8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

poly(ADP-ribose) polymerase 1 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  AAR2 splicing factor
  abraxas 1, BRCA1 A complex subunit
  agrin
  AKT serine/threonine kinase 2
  aldehyde dehydrogenase 16 family member A1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  anterior gradient 2, protein disulphide isomerase family member
  aprataxin
  aprataxin and PNKP like factor
  apurinic/apyrimidinic endodeoxyribonuclease 1
  A-Raf proto-oncogene, serine/threonine kinase
  ASH2 like, histone lysine methyltransferase complex subunit
  ataxin 3
  ATM serine/threonine kinase
  ATP synthase F1 subunit alpha
  ATRX, chromatin remodeler
  autoimmune regulator
  baculoviral IAP repeat containing 3
  BAF nuclear assembly factor 1
  BAG cochaperone 3
  BCL2 apoptosis regulator
  BH3-like motif containing, cell death inducer
  BLM RecQ like helicase
  BMI1 proto-oncogene, polycomb ring finger
  B-Raf proto-oncogene, serine/threonine kinase
  BRCA1 associated RING domain 1
  BRCA1 DNA repair associated
  BRCA2 DNA repair associated
  BRF1 RNA polymerase III transcription initiation factor subunit
  bromodomain and WD repeat domain containing 3
  bromodomain containing 7
  BTG3 associated nuclear protein
  BUB1 mitotic checkpoint serine/threonine kinase B
  BUB3 mitotic checkpoint protein
  calcium/calmodulin dependent protein kinase II beta
  cap methyltransferase 1
  caspase 1
  caspase 3
  caspase 7
  caspase 8
  catenin beta 1
  cathepsin B
  cathepsin G
  CCAAT enhancer binding protein alpha
  CCCTC-binding factor
  CD86 molecule
  CDK5 regulatory subunit associated protein 2
  cell division cycle 34, ubiqiutin conjugating enzyme
  cell division cycle 5 like
  centrin 1
  centrin 2
  centromere protein A
  centromere protein B
  checkpoint kinase 1
  checkpoint with forkhead and ring finger domains
  chromobox 2
  chromobox 4
  chromodomain helicase DNA binding protein 1 like
  chromodomain helicase DNA binding protein 3
  chromodomain helicase DNA binding protein 4
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  coronin 1C
  CREB binding protein
  CTD small phosphatase like 2
  cullin 4A
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 2
  cyclin dependent kinase 8
  cyclin dependent kinase 9
  cyclin dependent kinase inhibitor 1A
  CYLD lysine 63 deubiquitinase
  cytochrome P450 family 4 subfamily F member 12
  damage specific DNA binding protein 2
  death domain associated protein
  decapping enzyme, scavenger
  deltex E3 ubiquitin ligase 3L
  derlin 1
  DExD-box helicase 21
  DExD-box helicase 39A
  DNA ligase 1
  DNA ligase 3
  DNA methyltransferase 1
  DNA polymerase alpha 1, catalytic subunit
  DNA polymerase alpha 2, accessory subunit
  DNA polymerase beta
  DNA polymerase gamma 2, accessory subunit
  DNA topoisomerase I
  DNA topoisomerase II beta
  DNA topoisomerase II binding protein 1
  E1A binding protein p300
  E2F transcription factor 1
  ecdysoneless cell cycle regulator
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  epidermal growth factor receptor
  ERCC excision repair 6, chromatin remodeling factor
  estrogen receptor 1
  ETS proto-oncogene 1, transcription factor
  ETS transcription factor ERG
  eukaryotic translation initiation factor 3, subunit I
  EWS RNA binding protein 1
  exosome component 1
  FA complementation group D2
  Fas associated factor 1
  fibronectin 1
  flap structure-specific endonuclease 1
  forkhead box O1
  formin like 1
  galectin 3
  general transcription factor IIF subunit 1
  glycogen synthase kinase 3 alpha
  glycogen synthase kinase 3 beta
  granzyme B
  granzyme M
  H1.0 linker histone
  H1.1 linker histone, cluster member
  H1.2 linker histone, cluster member
  H1.5 linker histone, cluster member
  H2A clustered histone 18
  H2A clustered histone 4
  H2A.X variant histone
  H2A.Z variant histone 1
  H2B clustered histone 1
  H2B clustered histone 3
  H2B clustered histone 4
  H3 clustered histone 1
  H3 clustered histone 6
  H3.3 histone A
  H3.4 histone
  H4 clustered histone 1
  H4 clustered histone 3
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heparin binding growth factor
  hes family bHLH transcription factor 1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein H1
  HEXIM P-TEFb complex subunit 1
  high mobility group AT-hook 1
  high mobility group box 1
  high mobility group nucleosomal binding domain 2
  high mobility group nucleosomal binding domain 4
  high mobility group nucleosome binding domain 1
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 9
  histone PARylation factor 1
  HNF1 homeobox B
  homeobox B7
  homeodomain interacting protein kinase 2
  hypoxia inducible factor 1 subunit alpha
  influenza virus NS1A binding protein
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inner membrane mitochondrial protein
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  interferon regulatory factor 2
  interleukin 24
  interleukin enhancer binding factor 3
  Jun proto-oncogene, AP-1 transcription factor subunit
  Kin17 DNA and RNA binding protein
  kinase suppressor of ras 1
  Kruppel like factor 5
  Kruppel like factor 8
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  leucine zipper like transcription regulator 1
  lysine acetyltransferase 2B
  macroH2A.1 histone
  MAF bZIP transcription factor F
  MAF bZIP transcription factor G
  MAF bZIP transcription factor K
  mediator complex subunit 1
  mediator complex subunit 14
  mediator complex subunit 17
  mediator complex subunit 23
  mediator complex subunit 24
  mediator complex subunit 6
  mediator complex subunit 7
  metal regulatory transcription factor 1
  metastasis associated 1 family member 3
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 22
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated serine/threonine kinase 3
  mitogen-activated protein kinase 13
  mono-ADP ribosylhydrolase 1
  MORC family CW-type zinc finger 1
  MORC family CW-type zinc finger 2
  Mov10 RISC complex RNA helicase
  MYB proto-oncogene like 2
  MYB proto-oncogene, transcription factor
  MYC proto-oncogene, bHLH transcription factor
  N-acetyltransferase 10
  NAD(P)H quinone dehydrogenase 1
  NEDD8 ubiquitin like modifier
  neurofibromin 2
  neurotrophic receptor tyrosine kinase 1
  nipsnap homolog 2
  NK2 homeobox 1
  non-SMC condensin I complex subunit D2
  non-SMC condensin I complex subunit G
  notch receptor 1
  nuclear factor kappa B subunit 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear receptor binding SET domain protein 2
  nuclear receptor coactivator 6
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 3 group C member 1
  nuclear respiratory factor 1
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nucleolin
  nucleophosmin 1
  nucleophosmin 1
  obscurin like cytoskeletal adaptor 1
  ovo like zinc finger 2
  palmitoyl-protein thioesterase 1
  PDZ and LIM domain 7
  pellino E3 ubiquitin protein ligase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly (ADP-ribose) polymerase family, member 2
  poly(A) specific ribonuclease subunit PAN2
  poly(ADP-ribose) polymerase 1
  poly(ADP-ribose) polymerase 2
  poly(ADP-ribose) polymerase family member 3
  poly(ADP-ribose) polymerase family member 9
  polynucleotide kinase 3'-phosphatase
  potassium channel tetramerization domain containing 12
  POU class 2 homeobox 1
  PR/SET domain 16
  pre-mRNA processing factor 8
  progesterone receptor
  prohibitin
  proliferating cell nuclear antigen
  protein arginine methyltransferase 1
  protein inhibitor of activated STAT 4
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  protein tyrosine kinase 2
  PTEN induced kinase 1
  RAD18 E3 ubiquitin protein ligase
  RAD23 homolog A, nucleotide excision repair protein
  RAS like family 10 member B
  RE1 silencing transcription factor
  receptor like tyrosine kinase
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  replication protein A1
  replication protein A2
  replication protein A3
  replication protein A4
  retinoic acid receptor alpha
  retinoid X receptor alpha
  ribonucleotide reductase regulatory subunit M2
  ribosomal protein L10
  ribosomal protein L14
  ribosomal protein L19
  ribosomal protein L27a
  ribosomal protein L35
  ribosomal protein S3A
  ribosomal protein S8
  ribosomal RNA processing 1 homolog B (S. cerevisiae)
  ribosomal RNA processing 1B
  ring finger and CCCH-type domains 1
  ring finger protein 144A
  ring finger protein 146
  ring finger protein 166
  ring finger protein 168
  ring finger protein 4
  ring-box 1
  RIO kinase 2
  RNA binding motif protein 14
  secreted phosphoprotein 1
  sequestosome 1
  serine hydroxymethyltransferase 2
  SET domain containing 1A, histone lysine methyltransferase
  signal recognition particle 72
  sirtuin 1
  SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  snail family transcriptional repressor 1
  Sp1 transcription factor
  splicing regulatory glutamic acid and lysine rich protein 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  SRY-box transcription factor 2
  staphylococcal nuclease and tudor domain containing 1
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  structure specific recognition protein 1
  SUMO specific peptidase 1
  SUMO specific peptidase 3
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  switching B cell complex subunit SWAP70
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TATA-box binding protein associated factor 13
  TERF2 interacting protein
  thioredoxin interacting protein
  thymopoietin
  thyroid hormone receptor alpha
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor beta
  thyroid hormone responsive
  timeless circadian clock 1
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF interacting protein
  transcription elongation factor A2
  transcription factor 3
  transcription factor 4
  transcription factor 7 like 2
  transcription factor CP2
  tripartite motif containing 14
  tripartite motif containing 28
  tripartite motif containing 29
  tubulin beta 1 class VI
  tubulin beta class I
  tumor protein p53
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 M
  ubiquitin interaction motif containing 1
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 36
  unc-51 like autophagy activating kinase 1
  upstream transcription factor 1
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 1
  VRK serine/threonine kinase 3
  WD repeat domain 76
  WRN RecQ like helicase
  WW domain containing E3 ubiquitin protein ligase 2
  XPC complex subunit, DNA damage recognition and repair factor
  X-ray repair cross complementing 1
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 7A
  zinc finger and BTB domain containing 9
  zinc finger protein 365
  zinc finger protein 423
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.