P450-Glo™ Screening Systems Technical Bulletin

Instructions for Use of Product(s)
V9770, V9790, V9880, V9890, V9781, V9910, V9920

Literature # TB340

The P450-Glo™ Screening Systems provide a complete set of reagents for performing luminescent cytochrome P450 assays. The systems include a membrane preparation containing recombinant human cytochrome P450 enzyme, a luminogenic cytochrome P450 substrate appropriate for the enzyme, an NADPH Regeneration System, reaction buffer, Luciferin Detection Reagent and Luciferin-Free Water. The P450-Glo™ Screening Systems are ideal for testing the effects of drugs and new chemical entities on cytochrome P450 enzyme activities.

Summary of Changes
The following changes were made to the 3/22 revision of this document:
1. Removed discontinued product Cat.# V9800, affecting Sections 1, 3, 11 and 17.B.
2. Revised Section 17.C.
3. Updated disclaimers.
4. Updated cover page.

Revised 3/22.