Our wide selection of bioluminescent enzyme substrates for proteases and metabolic enzymes such as CYPs and MAO, among others, provide powerful tools for the ADME-Tox screen.
Get more data in less time when you multiplex cell health biomarkers. Measure one or multiple biomarkers in vitro or in situ to detect early or late events of apoptosis and get a quick status update on targeted cells.
Cell viability assay kits for easy measurement of viability in cell culture, 3D microtissues, bacterial cultures and virus-infected cells. Simple "add-mix-measure" protocols and convenient luminescent readout allow you to easily compare cell viability data from well-to-well, from plate-to-plate and from day-to-day.
Promega offers multiple readouts for quantifying cytotoxicity, including luminescent and fluorescent assays that can be multiplexed with apoptosis or viability assays to help determine mechanism of cell death.
Caspase-1 is an essential component of the inflammasome. Conversion of the procaspase-1 zymogen into catalytically active caspase-1 results in 1) the processing and release of cytokines, IL-1β and IL-18, and 2) pyroptosis, an immunogenic form of cell death. Promega introduces a homogenous, bioluminescent method to selectively measure caspase-1 activity directly from cells or medium.
NAD+, NADP+, NADH and NADPH are important cofactors for many enzymes involved in key cellular pathways, and quantitation of these dinucleotides is a standard approach to monitor enzyme activity directly or indirectly. Promega offers a number of systems to detect and quantify these important molecules.
A multiplexed, cell-based assay to monitor mitochondrial health. Measures ATP and a membrane integrity biomarker to distinguish mito-toxic mechanisms from other cytotoxic events.
Promega offers assays for detecting glutathione, measuring the ratio of reduced to oxidized glutathione and detecting changes in ROS as an indicator of cell health or cell signaling events.
Reporter vectors and cell lines containing response elements for monitoring activity of key cell signaling pathways.