SLC12A6, solute carrier family 12 member 6

SLC12A6, solute carrier family 12 member 6

• This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

• Gene Synonyms (solute carrier family 12 member 6, K-Cl cotransporter 3, electroneutral potassium-chloride cotransporter 3, potassium chloride cotransporter 3, potassium chloride cotransporter KCC3a-S3, potassium-chloride transporter-3a, potassium-chloride transporter-3b, solute carrier family 12 (potassium/chloride transporter), member 6, solute carrier family 12 (potassium/chloride transporters), member 6, ACCPN, KCC3, KCC3A, KCC3B,)
• NCBI Gene ID: 9990
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R9I5
  UNIPROT ID#>>Q6NSI7
  UNIPROT ID#>>A0A024R9K8
  UNIPROT ID#>>Q9UHW9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 12 member 6 interacts with:

• galectin 9C
  neuritin 1
  neuromedin U receptor 2
  serine/threonine kinase 39
  solute carrier family 17 member 2
  trans-golgi network protein 2
  transmembrane protein 17
  zinc and ring finger 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.