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RAPGEF5, Rap guanine nucleotide exchange factor 5

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RAPGEF5, Rap guanine nucleotide exchange factor 5

  • Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

  • Gene Synonyms (rap guanine nucleotide exchange factor 5, M-Ras-regulated GEF, M-Ras-regulated Rap GEF, Rap guanine nucleotide exchange factor (GEF) 5, guanine nucleotide exchange factor for Rap1, related to Epac, GFR, MR-GEF, REPAC,)
  • NCBI Gene ID: 9771
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>A8MQ07
    UNIPROT ID#>>Q92565
    UNIPROT ID#>>Q5JPD2
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rap guanine nucleotide exchange factor 5 interacts with:

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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