HAND2, heart and neural crest derivatives expressed 2

HAND2, heart and neural crest derivatives expressed 2

• The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]

• Gene Synonyms (heart- and neural crest derivatives-expressed protein 2, basic helix-loop-helix transcription factor HAND2, class A basic helix-loop-helix protein 26, deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, DHAND2, Hed, Thing2, bHLHa26, dHand,)
• NCBI Gene ID: 9464
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P61296
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heart and neural crest derivatives expressed 2 interacts with:

• COP9 signalosome subunit 5
  DNA methyltransferase 3 like
  family with sequence similarity 90 member A1
  heart and neural crest derivatives expressed 2
  hes related family bHLH transcription factor with YRPW motif 2
  hes related family bHLH transcription factor with YRPW motif like
  KN motif and ankyrin repeat domains 2
  PTEN induced kinase 1
  ripply transcriptional repressor 1
  SPANX family member N3
  ubiquitin specific peptidase 20

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.