PLPP2, phospholipid phosphatase 2

PLPP2, phospholipid phosphatase 2

• The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (phospholipid phosphatase 2, PAP2-gamma, PAP2c, lipid phosphate phosphohydrolase 2, phosphatidate phosphohydrolase type 2c, phosphatidic acid phosphatase 2c, phosphatidic acid phosphatase type 2C, phosphatidic acid phosphohydrolase type 2c, type-2 phosphatidic acid phosphatase-gamma, LPP2, PAP-2c, PAP2-g, PPAP2C,)
• NCBI Gene ID: 8612
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43688
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phospholipid phosphatase 2 interacts with:

• jagunal homolog 1
  mitochondrial ribosomal protein L44
  neuronal vesicle trafficking associated 1
  notch 2 N-terminal like A
  phospholipid phosphatase 2
  phospholipid phosphatase 3
  Rab9 effector protein with kelch motifs
  translocation associated membrane protein 1 like 1
  unc-119 lipid binding chaperone
  V-set and transmembrane domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.