GDF5, growth differentiation factor 5

GDF5, growth differentiation factor 5

• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016]

• Gene Synonyms (growth/differentiation factor 5, LPS-associated protein 4, bone morphogenetic protein 14, cartilage-derived morphogenetic protein-1, lipopolysaccharide-associated protein 4, radotermin, BDA1C, BMP-14, BMP14, CDMP1, DUPANS, LAP-4, LAP4, OS5, SYM1B, SYNS2,)
• NCBI Gene ID: 8200
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P43026
  UNIPROT ID#>>F1T0J1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

growth differentiation factor 5 interacts with:

• calmodulin like 5
  chordin like 2
  dual specificity phosphatase 14
  keratinocyte proline rich protein
  leucine rich repeat containing 15
  plakophilin 3
  RAB3A interacting protein
  selenium binding protein 1
  serpin family B member 7
  SNF related kinase
  transmembrane protein 102
  V-set and immunoglobulin domain containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.