ULBP2, UL16 binding protein 2

ULBP2, UL16 binding protein 2

• This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

• Gene Synonyms (UL16-binding protein 2, NKG2D ligand 2, retinoic acid early transcript 1H, retinoic acid early transcript 1L, ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, RAET1L,)
• NCBI Gene ID: 80328
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BZM5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

UL16 binding protein 2 interacts with:

• derlin 3
  gap junction protein beta 7
  indoleamine 2,3-dioxygenase 2
  retinoic acid early transcript 1E
  solute carrier family 39 member 5
  transmembrane protein 30B
  Yip1 domain family member 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.