BRCC3, BRCA1/BRCA2-containing complex subunit 3

BRCC3, BRCA1/BRCA2-containing complex subunit 3

• This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

• Gene Synonyms (lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36, BRCC36, C6.1A, CXorf53,)
• NCBI Gene ID: 79184
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P46736
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BRCA1/BRCA2-containing complex subunit 3 interacts with:

• abraxas 1, BRCA1 A complex subunit
  BRCA1 interacting protein C-terminal helicase 1
  BRCA1/BRCA2-containing complex subunit 3
  egl-9 family hypoxia inducible factor 3
  exocyst complex component 8
  NLR family pyrin domain containing 3
  rabaptin, RAB GTPase binding effector protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.