MAPKAPK3, MAPK activated protein kinase 3

MAPKAPK3, MAPK activated protein kinase 3

• This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

• Gene Synonyms (MAP kinase-activated protein kinase 3, MAPKAP kinase 3, chromosome 3p kinase, mitogen-activated protein kinase-activated protein kinase 3, 3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MDPT3, MK-3, MK3,)
• NCBI Gene ID: 7867
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16644
  UNIPROT ID#>>A0A024R2W7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAPK activated protein kinase 3 interacts with:

• beclin 1
  chromobox 4
  COP9 signalosome subunit 6
  eukaryotic elongation factor 2 kinase
  NEDD4 like E3 ubiquitin protein ligase
  protein tyrosine phosphatase domain containing 1
  protein tyrosine phosphatase non-receptor type 5
  RCSD domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.