TPBG, trophoblast glycoprotein

TPBG, trophoblast glycoprotein

• This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

• Gene Synonyms (trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, wnt-activated inhibitory factor 1, 5T4, 5T4AG, M6P1, WAIF1,)
• NCBI Gene ID: 7162
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13641
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

trophoblast glycoprotein interacts with:

• BUD31 homolog
  GIPC PDZ domain containing family member 1
  heterochromatin protein 1 binding protein 3
  nicastrin
  PC4 and SFRS1 interacting protein 1
  pre-mRNA processing factor 6
  RNA binding motif protein 14
  serine and arginine rich splicing factor 11
  SMU1 DNA replication regulator and spliceosomal factor
  splicing factor 3a subunit 1
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  ubiquitin specific peptidase 39

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.