ACE2, angiotensin I converting enzyme 2

ACE2, angiotensin I converting enzyme 2

• The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). [provided by RefSeq, Mar 2020]

• Gene Synonyms (angiotensin-converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme homolog, angiotensin-converting enzyme-related carboxypeptidase, metalloprotease MPROT15, peptidyl-dipeptidase A, ACEH,)
• NCBI Gene ID: 59272
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BYF1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

angiotensin I converting enzyme 2 interacts with:

• angiotensin I converting enzyme 2
  solute carrier family 6 member 19
  testis expressed 101
  transmembrane serine protease 11A

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