PACS1, phosphofurin acidic cluster sorting protein 1

PACS1, phosphofurin acidic cluster sorting protein 1

• This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MRD17, SHMS, phosphofurin acidic cluster sorting protein 1, PACS-1, cytosolic sorting protein PACS-1,)
• NCBI Gene ID: 55690
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R5H6
  UNIPROT ID#>>Q6VY07
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphofurin acidic cluster sorting protein 1 interacts with:

• FA core complex associated protein 100
  IQ motif containing F1
  transient receptor potential cation channel subfamily V member 4

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