OTUD5, OTU deubiquitinase 5

OTUD5, OTU deubiquitinase 5

• This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

• Gene Synonyms (DUBA, OTU domain-containing protein 5, OTU domain containing 5, deubiquinating enzyme A, deubiquitinating enzyme A,)
• NCBI Gene ID: 55593
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96G74
  UNIPROT ID#>>A0A024QZ09
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

OTU deubiquitinase 5 interacts with:

• CTP synthase 2
  egl-9 family hypoxia inducible factor 3
  F-box protein 38
  LanC like 2
  LON peptidase N-terminal domain and ring finger 2
  TNFAIP3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.