COQ3, coenzyme Q3, methyltransferase

COQ3, coenzyme Q3, methyltransferase

• Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

• Gene Synonyms (ubiquinone biosynthesis O-methyltransferase, mitochondrial, 2-polyprenyl-6-hydroxyphenol methylase, 2-polyprenyl-6-hydroxyphenyl methylase, 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, 3-demethylubiquinol 3-O-methyltransferase, 3-demethylubiquinone-10 3-methyltransferase, DHHB methyltransferase, DHHB-MTase, coenzyme Q3 homolog, methyltransferase, dihydroxyhexaprenylbenzoate methyltransferase, hexaprenyldihydroxybenzoate methyltransferase, mitochondrial, methyltransferase COQ3, polyprenyldihydroxybenzoate methyltransferase, DHHBMT, DHHBMTASE, UG0215E05, bA9819.1,)
• NCBI Gene ID: 51805
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NZJ6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coenzyme Q3, methyltransferase interacts with:

• coenzyme Q3, methyltransferase
  coenzyme Q5, methyltransferase
  coenzyme Q8A
  coenzyme Q8B
  coenzyme Q9
  NDRG family member 4

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