PIGP, phosphatidylinositol glycan anchor biosynthesis class P

PIGP, phosphatidylinositol glycan anchor biosynthesis class P

• This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

• Gene Synonyms (phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region gene 5, Down syndrome critical region protein 5, Down syndrome critical region protein C, phosphatidylinositol glycan, class P, phosphatidylinositol-glycan biosynthesis class P protein, phosphatidylinositol-n-acetylglucosaminyltranferase subunit, DCRC, DCRC-S, DSCR5, DSRC, EIEE55, PIG-P,)
• NCBI Gene ID: 51227
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P57054
  UNIPROT ID#>>A0A0C4DH71
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphatidylinositol glycan anchor biosynthesis class P interacts with:

• core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
  dehydrogenase/reductase X-linked
  LHFPL tetraspan subfamily member 3
  secretory carrier membrane protein 5
  small cell adhesion glycoprotein
  thrombospondin type 1 domain containing 7B
  transmembrane protein 107
  transmembrane protein 19
  transmembrane protein 229B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.