CLEC4G, C-type lectin domain family 4 member G

CLEC4G, C-type lectin domain family 4 member G

• This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

• Gene Synonyms (DTTR431, LP2698, LSECtin, UNQ431, C-type lectin domain family 4 member G, C-type lectin superfamily 4, member G, liver and lymph node sinusoidal endothelial cell C-type lectin,)
• NCBI Gene ID: 339390
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7ZKQ2
  UNIPROT ID#>>Q08G24
  UNIPROT ID#>>Q6XYD1
  UNIPROT ID#>>Q6UXB4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-type lectin domain family 4 member G interacts with:

• C-type lectin domain family 4 member G

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