TLX3, T cell leukemia homeobox 3

TLX3, T cell leukemia homeobox 3

• The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]

• Gene Synonyms (T-cell leukemia homeobox protein 3, homeo box 11-like 2, homeobox protein Hox-11L2, HOX11L2, RNX,)
• NCBI Gene ID: 30012
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43711
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

T cell leukemia homeobox 3 interacts with:

• amyloid beta precursor protein binding family B member 1 interacting protein
  ankyrin repeat and SOCS box containing 12
  ankyrin repeat domain 10
  ankyrin repeat domain 33
  armadillo repeat containing 5
  B9 domain containing 2
  BPI fold containing family A member 1
  chromosome 11 open reading frame 1
  chromosome 19 open reading frame 54
  chromosome 2 open reading frame 42
  family with sequence similarity 166 member B
  family with sequence similarity 168 member B
  fucose kinase
  gamma-glutamyltransferase light chain 2
  golgin A6 family like 9
  HOP homeobox
  hydroxypyruvate isomerase (putative)
  IGF like family member 2
  inhibitor of growth family member 4
  integrator complex subunit 11
  inter-alpha-trypsin inhibitor heavy chain family member 6
  keratin associated protein 11-1
  keratin associated protein 13-3
  keratin associated protein 19-1
  keratin associated protein 19-7
  keratin associated protein 3-1
  keratin associated protein 6-1
  keratin associated protein 6-2
  keratin associated protein 6-3
  keratin associated protein 7-1
  keratin associated protein 8-1
  methyltransferase like 27
  MORN repeat containing 5
  NHL repeat containing 4
  nicolin 1
  phospholipase A and acyltransferase 1
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  proteasome subunit beta 11
  ribosomal protein S6 kinase related
  saitohin
  SMU1 DNA replication regulator and spliceosomal factor
  spermatogenesis associated 46
  SPRY domain containing 7
  T-box transcription factor 22
  tektin 5
  testis expressed 37
  thiamine triphosphatase
  TOX high mobility group box family member 2
  transmembrane protein 42
  tripartite motif containing 42
  UFM1 specific peptidase 1 (inactive)
  WD repeat domain 83
  yippee like 3
  zinc finger protein 34
  zinc finger protein 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.