ICMT, isoprenylcysteine carboxyl methyltransferase

ICMT, isoprenylcysteine carboxyl methyltransferase

• This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein-S-isoprenylcysteine O-methyltransferase, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT,)
• NCBI Gene ID: 23463
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4F6
  UNIPROT ID#>>B3KS61
  UNIPROT ID#>>O60725
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

isoprenylcysteine carboxyl methyltransferase interacts with:

• ADP ribosylation factor like GTPase 13B
  armadillo repeat containing 8
  dual specificity phosphatase 28
  grancalcin
  jagunal homolog 1
  pleckstrin homology domain containing A4
  ring finger protein 19B
  transmembrane protein 41B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.