ARHGEF12, Rho guanine nucleotide exchange factor 12

ARHGEF12, Rho guanine nucleotide exchange factor 12

• Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

• Gene Synonyms (LARG, PRO2792, rho guanine nucleotide exchange factor 12, Rho guanine nucleotide exchange factor (GEF) 12, leukemia-associated RhoGEF, leukemia-associated rho guanine nucleotide exchange factor,)
• NCBI Gene ID: 23365
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E9PMR6
  UNIPROT ID#>>B4E2K6
  UNIPROT ID#>>Q9NZN5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 12 interacts with:

• coiled-coil domain containing 183
  extra spindle pole bodies 1, separase
  GIPC PDZ domain containing family member 2
  kelch like family member 20
  pleckstrin homology domain containing A4
  plexin B2
  Rho guanine nucleotide exchange factor 12
  Rho guanine nucleotide exchange factor 40
  SH3 domain binding protein 4
  solute carrier family 25 member 41
  tRNA methyltransferase 61A
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.