SNX13, sorting nexin 13

SNX13, sorting nexin 13

• This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]

• Gene Synonyms (RGS-PX1, sorting nexin-13, rgs domain- and phox domain-containing protein,)
• NCBI Gene ID: 23161
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86XC4
  UNIPROT ID#>>Q9Y5W8
  UNIPROT ID#>>A0A024R9Z9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sorting nexin 13 interacts with:

• inositol-pentakisphosphate 2-kinase
  Kruppel like factor 15
  transmembrane protein adipocyte associated 1
  tyrosyl-DNA phosphodiesterase 2

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