PEG10, paternally expressed 10

PEG10, paternally expressed 10

• This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

• Gene Synonyms (EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3, RTL2, SIRH1, retrotransposon-derived protein PEG10, MEF3 like 1, Sushi-Ichi retrotransposon homolog 1, embryonal carcinoma differentiation regulated, mammalian retrotransposon-derived 2, mammalian retrotransposon-derived protein 2, myelin expression factor 3-like protein 1, paternally expressed gene 10 protein, retrotransposon Gag like 2, retrotransposon gag domain-containing protein 3, retrotransposon-derived gag-like polyprotein, ty3/Gypsy-like protein,)
• NCBI Gene ID: 23089
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86TG7
  UNIPROT ID#>>B4DSP0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

paternally expressed 10 interacts with:

• centrosomal protein 290
  exosome component 5
  LDOC1 regulator of NFKB signaling
  ligand of numb-protein X 2
  mindbomb E3 ubiquitin protein ligase 1
  N-acetylneuraminate pyruvate lyase
  Nanog homeobox
  pleckstrin homology domain containing A4
  RAB3A interacting protein
  retrotransposon Gag like 8A
  retrotransposon Gag like 8B
  ribosomal protein L35
  ring finger and CCCH-type domains 1
  ring finger protein 181
  Shoc2, leucine rich repeat scaffold protein
  timeless interacting protein
  toll interacting protein
  vir like m6A methyltransferase associated
  zinc finger protein 512B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.