SETX, senataxin

SETX, senataxin

• This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]

• Gene Synonyms (ALS4, AOA2, SCAN2, SCAR1, Sen1, bA479K20.2, probable helicase senataxin, SEN1 homolog, amyotrophic lateral sclerosis 4 protein,)
• NCBI Gene ID: 23064
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z333
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

senataxin interacts with:

• cadherin 19
  catechol-O-methyltransferase domain containing 1
  CD2 associated protein
  centrobin, centriole duplication and spindle assembly protein
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 120B
  lipocalin 15
  MTOR associated protein, LST8 homolog
  neurogenin 3
  NHS-like 1
  PNKD metallo-beta-lactamase domain containing
  regulation of nuclear pre-mRNA domain containing 1B
  ring finger protein 123
  SIGLEC family like 1
  SUZ12 polycomb repressive complex 2 subunit
  vir like m6A methyltransferase associated
  VPS28 subunit of ESCRT-I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.