CYP3A4, cytochrome P450 family 3 subfamily A member 4

CYP3A4, cytochrome P450 family 3 subfamily A member 4

• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

• Gene Synonyms (cytochrome P450 3A4, 1,4-cineole 2-exo-monooxygenase, 1,8-cineole 2-exo-monooxygenase, P450-III, steroid inducible, albendazole monooxygenase, albendazole monooxygenase (sulfoxide-forming), albendazole sulfoxidase, cholesterol 25-hydroxylase, cytochrome P450 3A3, cytochrome P450 HLp, cytochrome P450 NF-25, cytochrome P450, family 3, subfamily A, polypeptide 4, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, cytochrome P450-PCN1, glucocorticoid-inducible P450, nifedipine oxidase, quinine 3-monooxygenase, taurochenodeoxycholate 6-alpha-hydroxylase, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1,)
• NCBI Gene ID: 1576
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6GRK0
  UNIPROT ID#>>P08684
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome P450 family 3 subfamily A member 4 interacts with:

• cytochrome P450 family 3 subfamily A member 4
  cytochrome p450 oxidoreductase
  glycerol kinase
  heat shock protein family A (Hsp70) member 8
  progesterone receptor membrane component 1
  protein kinase C alpha
  protein kinase cAMP-activated catalytic subunit alpha
  STIP1 homology and U-box containing protein 1
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 G1
  UDP glucuronosyltransferase family 1 member A1
  UDP glucuronosyltransferase family 1 member A6
  UDP glucuronosyltransferase family 2 member B7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.