- Gene Overview
- Interaction Network
- Sequence Verification
CYP1A2, cytochrome P450 family 1 subfamily A member 2
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
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Gene Synonyms (cytochrome P450 1A2, P450 form 4, aryl hydrocarbon hydroxylase, cholesterol 25-hydroxylase, cytochrome P(3)450, cytochrome P450 4, cytochrome P450, family 1, subfamily A, polypeptide 2, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2, cytochrome P450-P3, dioxin-inducible P3-450, flavoprotein-linked monooxygenase, hydroperoxy icosatetraenoate dehydratase, microsomal monooxygenase, xenobiotic monooxygenase, CP12, CYPIA2, P3-450, P450(PA),)
- NCBI Gene ID:
1544
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P05177
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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cytochrome P450 family 1 subfamily A member 2 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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