MSL3, MSL complex subunit 3

MSL3, MSL complex subunit 3

• This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

• Gene Synonyms (MRSXBA, MRXS36, MRXSBA, MSL3L1, male-specific lethal 3 homolog, MSL3-like 1, male-specific lethal-3 protein-like 1,)
• NCBI Gene ID: 10943
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N5Y2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MSL complex subunit 3 interacts with:

• biorientation of chromosomes in cell division 1
  centrosomal protein 43
  H4 histone 16
  K(lysine) acetyltransferase 8
  lysine acetyltransferase 8
  MSL complex subunit 1
  MSL complex subunit 2
  PAF1 homolog, Paf1/RNA polymerase II complex component
  pleckstrin homology domain containing A1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.