PLEKHA1, pleckstrin homology domain containing A1

PLEKHA1, pleckstrin homology domain containing A1

• This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]

• Gene Synonyms (pleckstrin homology domain-containing family A member 1, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1, tandem PH domain-containing protein 1, TAPP1,)
• NCBI Gene ID: 59338
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KQL5
  UNIPROT ID#>>Q9HB21
  UNIPROT ID#>>Q5RGS4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleckstrin homology domain containing A1 interacts with:

• centrosomal protein 19
  pleckstrin homology domain containing A2
  sodium channel and clathrin linker 1
  transmembrane protein 17

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