OGA, O-GlcNAcase

OGA, O-GlcNAcase

• The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (MEA5, MGEA5, NCOAT, protein O-GlcNAcase, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase, beta-N-acetylglucosaminidase, beta-N-acetylhexosaminidase, beta-hexosaminidase, bifunctional protein NCOAT, hyaluronidase in meningioma, meningioma expressed antigen 5 (hyaluronidase), meningioma-expressed antigen 5, nuclear cytoplasmic O-GlcNAcase and acetyltransferase,)
• NCBI Gene ID: 10724
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60502
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

O-GlcNAcase interacts with:

• base methyltransferase of 25S rRNA 2 homolog
  C1q and TNF related 9
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 19
  chromobox 8
  ER membrane protein complex subunit 9
  lactamase beta 2
  limb development membrane protein 1 like
  MAGE family member D2
  microtubule associated serine/threonine kinase 1
  PAX interacting protein 1
  PITH domain containing 1
  protein phosphatase 1 regulatory subunit 18
  ring finger protein 32
  SIN3 transcription regulator family member A
  STN1 subunit of CST complex
  testin LIM domain protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.