ACOT8, acyl-CoA thioesterase 8

ACOT8, acyl-CoA thioesterase 8

• The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

• Gene Synonyms (acyl-coenzyme A thioesterase 8, HIV-Nef associated acyl-CoA thioesterase, Nef (lentivirus myristoylated factor) associated protein 1, choloyl-CoA hydrolase, choloyl-coenzyme A thioesterase, long-chain fatty-acyl-CoA hydrolase, palmitoyl-CoA hydrolase, peroxisomal acyl-CoA thioesterase 1, peroxisomal acyl-CoA thioesterase 2, peroxisomal acyl-coenzyme A thioester hydrolase 1, peroxisomal long-chain acyl-CoA thioesterase 1, thioesterase II, thioesterase III, HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE,)
• NCBI Gene ID: 10005
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14734
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

acyl-CoA thioesterase 8 interacts with:

• F-box protein 7
  kelch like family member 23
  myotubularin related protein 14
  neural precursor cell expressed, developmentally down-regulated gene 1
  pleckstrin homology domain containing A4
  PR/SET domain 16
  prolyl 4-hydroxylase subunit alpha 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.