TRMT1, tRNA methyltransferase 1

TRMT1, tRNA methyltransferase 1

• This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]

• Gene Synonyms (MRT68, TRM1, tRNA (guanine(26)-N(2))-dimethyltransferase, N(2),N(2)-dimethylguanosine tRNA methyltransferase, TRM1 tRNA methyltransferase 1 homolog, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA methyltransferase 1 homolog, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase,)
• NCBI Gene ID: 55621
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NXH9
  UNIPROT ID#>>A0A024R7I5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tRNA methyltransferase 1 interacts with:

• alanyl-tRNA synthetase 2, mitochondrial
  D-2-hydroxyglutarate dehydrogenase
  dipeptidyl peptidase 9
  lipase H
  NADH:ubiquinone oxidoreductase subunit A12
  pleckstrin homology domain containing A4
  ret finger protein like 4B
  thioredoxin domain containing 5
  THUMP domain containing 2
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.