RUNX1, RUNX family transcription factor 1

RUNX1, RUNX family transcription factor 1

• Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (runt-related transcription factor 1, AML1-EVI-1 fusion protein, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, acute myeloid leukemia 1 protein, core-binding factor, runt domain, alpha subunit 2, mutant RUNX1, oncogene AML-1, polyomavirus enhancer-binding protein 2 alpha B subunit, runt related transcription factor 1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha,)
• NCBI Gene ID: 861
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q01196
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RUNX family transcription factor 1 interacts with:

• 5'-3' exoribonuclease 2
  arginyl-tRNA synthetase 1
  ASH2 like, histone lysine methyltransferase complex subunit
  AT-rich interaction domain 1A
  AT-rich interaction domain 3A
  BAG cochaperone 3
  BAG cochaperone 4
  bromodomain containing 9
  catenin beta 1
  CBFA2/RUNX1 partner transcriptional co-repressor 2
  CBFA2/RUNX1 partner transcriptional co-repressor 3
  CCAAT enhancer binding protein alpha
  CCAAT enhancer binding protein beta
  CDKN2A interacting protein
  cell division cycle 16
  centrosomal protein 72
  clathrin heavy chain
  cleavage and polyadenylation specific factor 3
  cleavage and polyadenylation specific factor 6
  cleavage stimulation factor subunit 2
  cleavage stimulation factor subunit 2 tau variant
  coordinator of PRMT5 and differentiation stimulator
  core binding factor beta
  core-binding factor subunit beta
  CREB binding protein
  C-terminal binding protein 1
  C-terminal binding protein 2
  CTP synthase 1
  cyclin D2
  cyclin D3
  cyclin dependent kinase 1
  cyclin dependent kinase 6
  cyclin dependent kinase 9
  cyclin K
  DAZ interacting zinc finger protein 3
  DEAD-box helicase 1
  DEAD-box helicase 17
  DEAD-box helicase 3 X-linked
  DEAD-box helicase 41
  DEAD-box helicase 5
  DEAH-box helicase 15
  DEAH-box helicase 36
  decapping enzyme, scavenger
  deleted in malignant brain tumors 1
  deltex E3 ubiquitin ligase 2
  DExD-box helicase 21
  DExH-box helicase 9
  dihydropyrimidinase like 2
  DNA methyltransferase 1
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B11
  double PHD fingers 2
  dynein light chain LC8-type 1
  E1A binding protein p300
  E74 like ETS transcription factor 1
  E74 like ETS transcription factor 2
  E74 like ETS transcription factor 4
  ELAV like RNA binding protein 1
  EMG1 N1-specific pseudouridine methyltransferase
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 alpha 2
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit G
  eukaryotic translation initiation factor 4A2
  EWS RNA binding protein 1
  ezrin
  FA complementation group D2
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 222 member B
  far upstream element binding protein 1
  Fas associated factor 1
  F-box protein 17
  fermitin family member 3
  forkhead box P3
  Fos proto-oncogene, AP-1 transcription factor subunit
  four and a half LIM domains 2
  FUS RNA binding protein
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  GRIP and coiled-coil domain containing 1
  guanine monophosphate synthase
  H4 clustered histone 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  HIC ZBTB transcriptional repressor 2
  histone deacetylase 1
  histone deacetylase 11
  histone deacetylase 2
  histone deacetylase 3
  homeodomain interacting protein kinase 1
  homeodomain interacting protein kinase 2
  homeodomain interacting protein kinase 2
  hypoxia inducible factor 1 subunit alpha
  IKAROS family zinc finger 1
  IKAROS family zinc finger 3
  insulin like growth factor 2 mRNA binding protein 1
  integrator complex subunit 10
  integrator complex subunit 9
  Jun proto-oncogene, AP-1 transcription factor subunit
  KH-type splicing regulatory protein
  kinesin family member 2B
  Kruppel like factor 6
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  lamin B1
  leucine rich repeat containing 40
  leucine rich repeats and WD repeat domain containing 1
  lymphocyte cytosolic protein 1
  lysine acetyltransferase 6A
  lysine acetyltransferase 6B
  lysine methyltransferase 2A
  major histocompatibility complex, class II, DM alpha
  mediator complex subunit 1
  mediator complex subunit 12
  mediator complex subunit 16
  mediator complex subunit 17
  mediator complex subunit 26
  menin 1
  metastasis associated 1 family member 2
  mitogen-activated protein kinase 1
  mitotic arrest deficient 2 like 2
  MLLT1 super elongation complex subunit
  MYC proto-oncogene, bHLH transcription factor
  myogenic differentiation 1
  NDC80 kinetochore complex component
  NEDD4 E3 ubiquitin protein ligase
  negative elongation factor complex member B
  NFKB inhibitor delta
  NK2 homeobox 1
  non-POU domain containing octamer binding
  NOP56 ribonucleoprotein
  notch receptor 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear receptor subfamily 4 group A member 2
  nucleoporin 85
  oligodendrocyte transcription factor 3
  origin recognition complex subunit 2
  paired box 5
  paraspeckle component 1
  PAX interacting protein 1
  PC4 and SFRS1 interacting protein 1
  PML nuclear body scaffold
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  protein arginine methyltransferase 1
  protein arginine methyltransferase 5
  RAD18 E3 ubiquitin protein ligase
  Ran GTPase activating protein 1
  RB binding protein 5, histone lysine methyltransferase complex subunit
  recombination activating 1
  replication protein A1
  retinoic acid receptor alpha
  ring finger protein 38
  ring finger protein 44
  RNA binding motif protein 14
  RNA binding motif protein 39
  RNA polymerase II associated protein 2
  RUNX family transcription factor 1
  RUNX1 partner transcriptional co-repressor 1
  siah E3 ubiquitin protein ligase 1
  signal recognition particle 68
  SIN3 transcription regulator family member A
  SMAD family member 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 5
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein polypeptide C
  small nuclear ribonucleoprotein U1 subunit 70
  sorting nexin 9
  spen family transcriptional repressor
  Spi-1 proto-oncogene
  splicing factor 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor proline and glutamine rich
  SRY-box transcription factor 2
  STIP1 homology and U-box containing protein 1
  suppressor of variegation 3-9 homolog 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  tafazzin
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TATA-box binding protein associated factor 15
  TEA domain transcription factor 2
  TEA domain transcription factor 4
  tektin 5
  TLE family member 1, transcriptional corepressor
  TLE family member 2, transcriptional corepressor
  TNF receptor associated factor 6
  TNF receptor associated protein 1
  transcription factor 12
  transcription factor 3
  transferrin receptor
  transketolase
  tripartite motif containing 25
  tripartite motif containing 33
  tripartite motif containing 5
  tubulin alpha 1b
  tubulin beta 2A class IIa
  U2 snRNP associated SURP domain containing
  ubiquitin conjugating enzyme E2 L6
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 39
  ubiquitously expressed prefoldin like chaperone
  upstream binding protein 1
  vir like m6A methyltransferase associated
  vitamin D receptor
  VPS37C subunit of ESCRT-I
  WD repeat and coiled coil containing
  WD repeat domain 76
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing transcription regulator 1
  X-ray repair cross complementing 6
  Yes1 associated transcriptional regulator
  zinc finger protein 131
  zinc finger protein 326

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.