CA12, carbonic anhydrase 12

CA12, carbonic anhydrase 12

• Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

• Gene Synonyms (carbonic anhydrase 12, carbonate dehydratase XII, carbonic anhydrase XII, carbonic dehydratase, tumor antigen HOM-RCC-3.1.3, CA-XII, CAXII, HsT18816, T18816,)
• NCBI Gene ID: 771
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43570
  UNIPROT ID#>>B3KUB4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

carbonic anhydrase 12 interacts with:

• carbonic anhydrase 12
  cut like homeobox 1
  death domain associated protein
  galectin 7B
  katanin regulatory subunit B1 like 1
  KRAS proto-oncogene, GTPase
  mitochondrial ribosomal protein L9
  mitogen-activated protein kinase 6
  retinol dehydrogenase 11
  ring finger protein 123
  ring finger protein 4
  small G protein signaling modulator 2
  target of EGR1, exonuclease
  transmembrane protein 30B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.