BMP8B, bone morphogenetic protein 8b

BMP8B, bone morphogenetic protein 8b

• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

• Gene Synonyms (bone morphogenetic protein 8B, bone morphogenetic protein 8 (osteogenic protein 2), osteogenic protein 2, BMP8, OP2,)
• NCBI Gene ID: 656
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P34820
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

bone morphogenetic protein 8b interacts with:

• bone morphogenetic protein 8b
  cullin 1
  Mov10 RISC complex RNA helicase
  nuclear RNA export factor 1
  plasminogen activator, urokinase receptor
  serine hydroxymethyltransferase 2
  tafazzin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.