ATR, ATR serine/threonine kinase

ATR, ATR serine/threonine kinase

• The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

• Gene Synonyms (serine/threonine-protein kinase ATR, FRAP-related protein-1, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3-related protein, FCTCS, FRP1, MEC1, SCKL, SCKL1,)
• NCBI Gene ID: 545
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13535
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATR serine/threonine kinase interacts with:

• 5-hydroxytryptamine receptor 6
  5'-nucleotidase ecto
  adaptor related protein complex 3 subunit beta 1
  apoptosis antagonizing transcription factor
  ATM interactor
  ATR interacting protein
  ATR serine/threonine kinase
  basigin (Ok blood group)
  BH3 interacting domain death agonist
  BLM RecQ like helicase
  branched chain amino acid transaminase 2
  BRCA1 DNA repair associated
  BRCA2 DNA repair associated
  cAMP responsive element binding protein 1
  carbonic anhydrase 14
  CD274 molecule
  CEA cell adhesion molecule 21
  cell division cycle 5 like
  cell division cycle 6
  centrosomal protein 164
  checkpoint kinase 1
  checkpoint kinase 2
  chromodomain helicase DNA binding protein 4
  claspin
  clathrin heavy chain
  component of inhibitor of nuclear factor kappa B kinase complex
  C-terminal binding protein 2
  cyclin B2
  cyclin dependent kinase 2
  cyclin dependent kinase 2 interacting protein
  cyclin dependent kinase 9
  cyclin dependent kinase inhibitor 2A
  cyclin dependent kinase inhibitor 2C
  DDB1 and CUL4 associated factor 1
  denticleless E3 ubiquitin protein ligase homolog
  DNA cross-link repair 1C
  DNA ligase 4
  DNA polymerase delta 1, catalytic subunit
  DNA polymerase nu
  DNA topoisomerase II binding protein 1
  E1A binding protein p300
  E2F transcription factor 1
  E4F transcription factor 1
  ectodysplasin A
  epidermal growth factor receptor
  ETAA1 activator of ATR kinase
  ETS variant transcription factor 1
  eukaryotic translation elongation factor 1 epsilon 1
  FA complementation group A
  FA complementation group D2
  FA complementation group I
  FA core complex associated protein 24
  family with sequence similarity 133 member B
  F-box protein 32
  fms related receptor tyrosine kinase 1
  glycophorin A (MNS blood group)
  glycophorin B (MNS blood group)
  H2A.X variant histone
  H4 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 4
  helicase, POLQ like
  histone deacetylase 1
  histone deacetylase 2
  HUS1 checkpoint clamp component
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  integrator complex subunit 3
  kinase insert domain receptor
  KRAS proto-oncogene, GTPase
  LY6/PLAUR domain containing 3
  macrophage stimulating 1 receptor
  metastasis associated 1
  metastasis associated 1 family member 2
  microcephalin 1
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 7
  MRE11 homolog, double strand break repair nuclease
  mutS homolog 2
  mutS homolog 6
  myotubularin related protein 4
  natural killer cell cytotoxicity receptor 3 ligand 1
  nibrin
  nitric oxide synthase interacting protein
  nuclear receptor coactivator 2
  opioid receptor mu 1
  partner and localizer of BRCA2
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phospholipase A2 group IVC
  platelet derived growth factor receptor beta
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  PMS1 homolog 1, mismatch repair system component
  poly(A) binding protein nuclear 1
  POU class 5 homeobox 1
  progesterone receptor membrane component 1
  proliferation-associated 2G4
  protein phosphatase 2 regulatory subunit B''alpha
  PTEN induced kinase 1
  PVR cell adhesion molecule
  RAD1 checkpoint DNA exonuclease
  RAD17 checkpoint clamp loader component
  RAD9 checkpoint clamp component A
  Ras association domain family member 1
  Ras homolog, mTORC1 binding
  replication protein A1
  replication protein A2
  replication protein A3
  Rho guanine nucleotide exchange factor 1
  scavenger receptor class A member 3
  Smad nuclear interacting protein 1
  SNW domain containing 1
  sodium voltage-gated channel beta subunit 2
  sodium voltage-gated channel beta subunit 3
  splA/ryanodine receptor domain and SOCS box containing 1
  structural maintenance of chromosomes 1A
  suppressor of cytokine signaling 1
  synaptonemal complex protein 3
  TELO2 interacting protein 1
  telomerase reverse transcriptase
  telomere maintenance 2
  TNF receptor superfamily member 1A
  TNF superfamily member 8
  tubulin gamma 1
  tumor protein p53
  tumor protein p53 binding protein 1
  tumor protein, translationally-controlled 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 20
  UPF1 RNA helicase and ATPase
  vasorin
  vir like m6A methyltransferase associated
  V-set and immunoglobulin domain containing 1
  V-set and immunoglobulin domain containing 2
  WRN RecQ like helicase
  XPA, DNA damage recognition and repair factor
  XPC complex subunit, DNA damage recognition and repair factor
  X-ray repair cross complementing 5
  Y-box binding protein 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.