LTB, lymphotoxin beta

LTB, lymphotoxin beta

• Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (TNFC, TNFSF3, TNLG1C, p33, lymphotoxin-beta, LT-beta, TNF superfamily member 3, TNF-C, lymphotoxin beta (TNF superfamily, member 3), tumor necrosis factor C, tumor necrosis factor ligand 1C, tumor necrosis factor ligand superfamily member 3,)
• NCBI Gene ID: 4050
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5STB2
  UNIPROT ID#>>Q06643
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lymphotoxin beta interacts with:

• lymphotoxin beta
  lymphotoxin beta receptor
  TNF receptor superfamily member 1A
  TNF superfamily member 14

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