RHOC, ras homolog family member C

RHOC, ras homolog family member C

• This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (rho-related GTP-binding protein RhoC, RAS-related homolog 9, epididymis secretory sperm binding protein, oncogene RHO H9, ras homolog gene family, member C, rho cDNA clone 9, rhoC GTPase, small GTP binding protein RhoC, ARH9, ARHC, H9, RHOH9,)
• NCBI Gene ID: 389
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R0I3
  UNIPROT ID#>>P08134
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ras homolog family member C interacts with:

• actin related protein 10
  activating transcription factor 2
  anterior gradient 2, protein disulphide isomerase family member
  cathepsin A
  caveolin 1
  chromosome 1 open reading frame 198
  citron rho-interacting serine/threonine kinase
  cyclin dependent kinase 2
  developmental pluripotency-associated 3
  diaphanous related formin 1
  dishevelled associated activator of morphogenesis 1
  dishevelled associated activator of morphogenesis 2
  estrogen receptor 2
  G protein subunit beta 2
  galactosidase beta 1
  ligand of numb-protein X 1
  lysosomal associated membrane protein 1
  protein phosphatase 3 catalytic subunit alpha
  Rac family small GTPase 1
  Rac family small GTPase 3
  Rap1 GTPase-GDP dissociation stimulator 1
  Rho associated coiled-coil containing protein kinase 1
  RHO family interacting cell polarization regulator 2
  Rho GDP dissociation inhibitor alpha
  Rho GDP dissociation inhibitor beta
  Rho GTPase activating protein 1
  Rho guanine nucleotide exchange factor 1
  Rho guanine nucleotide exchange factor 11
  Rho guanine nucleotide exchange factor 12
  rhotekin
  rhotekin 2
  RIPOR family member 3
  tubulin alpha 1a
  von Hippel-Lindau tumor suppressor
  zinc finger MYM-type containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.