TSC22D3, TSC22 domain family member 3

TSC22D3, TSC22 domain family member 3

• This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

• Gene Synonyms (DIP, DSIPI, GILZ, TSC-22R, TSC22 domain family protein 3, DSIP-immunoreactive leucine zipper protein, DSIP-immunoreactive peptide, TSC-22 related protein, TSC-22-like protein, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein,)
• NCBI Gene ID: 1831
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5JRJ2
  UNIPROT ID#>>Q99576
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TSC22 domain family member 3 interacts with:

• ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  CDC42 small effector 2
  centrosomal protein 55
  chromosome 19 open reading frame 57
  c-src tyrosine kinase
  doublecortin like kinase 2
  ELAV like RNA binding protein 1
  endonuclease V
  EP300 interacting inhibitor of differentiation 3
  family with sequence similarity 117 member B
  fidgetin like 1
  Fos proto-oncogene, AP-1 transcription factor subunit
  heat shock protein family A (Hsp70) member 8
  hippocalcin like 4
  histone deacetylase 1
  histone deacetylase 2
  IQ motif containing N
  Jun proto-oncogene, AP-1 transcription factor subunit
  MDM2 proto-oncogene
  metastasis associated 1 family member 2
  mitotic arrest deficient 1 like 1
  myogenic differentiation 1
  NEDD4 like E3 ubiquitin protein ligase
  nuclear factor kappa B subunit 1
  nuclear factor kappa B subunit 2
  nuclear FMR1 interacting protein 2
  nuclear receptor binding protein 1
  phosphoenolpyruvate carboxykinase 1
  pleckstrin homology and FYVE domain containing 2
  Raf-1 proto-oncogene, serine/threonine kinase
  RCC1 domain containing 1
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  serum/glucocorticoid regulated kinase 1
  sirtuin 6
  small ubiquitin like modifier 1
  sodium channel epithelial 1 subunit beta
  TSC22 domain family member 1
  TSC22 domain family member 2
  TSC22 domain family member 3
  TSC22 domain family member 4
  tumor protein p53
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin protein ligase E3D

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.