CPN1, carboxypeptidase N subunit 1

CPN1, carboxypeptidase N subunit 1

• Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

• Gene Synonyms (carboxypeptidase N catalytic chain, anaphylatoxin inactivator, arginine carboxypeptidase, carboxypeptidase K, carboxypeptidase N catalytic subunit, carboxypeptidase N polypeptide 1 50 kD, carboxypeptidase N small subunit, carboxypeptidase N, polypeptide 1, kininase I, kininase-1, lysine carboxypeptidase, plasma carboxypeptidase B, serum carboxypeptidase N, CPN, SCPN,)
• NCBI Gene ID: 1369
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P15169
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

carboxypeptidase N subunit 1 interacts with:

• BTB domain containing 1
  carboxypeptidase N subunit 1
  carboxypeptidase N subunit 2
  centrosomal protein 170
  C-type lectin domain family 4 member G
  kininogen 1
  lysine demethylase 3B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.