BMI1, BMI1 proto-oncogene, polycomb ring finger

BMI1, BMI1 proto-oncogene, polycomb ring finger

• This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

• Gene Synonyms (polycomb complex protein BMI-1, B lymphoma Mo-MLV insertion region 1 homolog, BMI1 polycomb ring finger oncogene, BMI1 polycomb ring finger proto-oncogene, murine leukemia viral (bmi-1) oncogene homolog, polycomb group RING finger protein 4, polycomb group protein Bmi1, ring finger protein 51, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1,)
• NCBI Gene ID: 648
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35226
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BMI1 proto-oncogene, polycomb ring finger interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  5'-3' exoribonuclease 1
  5'-3' exoribonuclease 2
  activity dependent neuroprotector homeobox
  acylglycerol kinase
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  A-kinase anchoring protein 9
  alanyl-tRNA synthetase 2, mitochondrial
  apolipoprotein B mRNA editing enzyme catalytic subunit 3F
  apoptosis inducing factor mitochondria associated 1
  apoptotic chromatin condensation inducer 1
  aquarius intron-binding spliceosomal factor
  ARFGEF family member 3
  arginine and serine rich coiled-coil 1
  argonaute RISC catalytic component 2
  argonaute RISC component 1
  ASXL transcriptional regulator 1
  ataxin 2
  ataxin 2 like
  ATP binding cassette subfamily B member 6 (Langereis blood group)
  BAF nuclear assembly factor 1
  BCL2 associated transcription factor 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BMI1 proto-oncogene, polycomb ring finger
  bromodomain adjacent to zinc finger domain 1A
  bromodomain adjacent to zinc finger domain 1B
  bromodomain containing 4
  BUD31 homolog
  calcium homeostasis endoplasmic reticulum protein
  calmodulin 1
  calnexin
  capping actin protein of muscle Z-line subunit beta
  CASC3 exon junction complex subunit
  casein kinase 2 alpha 1
  casein kinase 2 beta
  catenin delta 1
  Cbl proto-oncogene
  CCCTC-binding factor
  CCHC-type zinc finger nucleic acid binding protein
  CDKN1A interacting zinc finger protein 1
  cell cycle associated protein 1
  cell division cycle 6
  centromere protein A
  centromere protein V
  centrosomal protein 126
  chaperonin containing TCP1 subunit 3
  chromatin target of PRMT1
  chromobox 2
  chromobox 2
  chromobox 3
  chromobox 4
  chromobox 5
  chromobox 6
  chromobox 7
  chromobox 7
  chromobox 8
  chromodomain helicase DNA binding protein 3
  chromodomain helicase DNA binding protein 4
  cilia and flagella associated protein 20
  cleavage stimulation factor subunit 1
  CLN6 transmembrane ER protein
  cold inducible RNA binding protein
  creatine kinase, mitochondrial 1B
  CREB binding protein
  crooked neck pre-mRNA splicing factor 1
  CUGBP Elav-like family member 1
  cullin 3
  cullin 4A
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase inhibitor 3
  cysteine and glycine rich protein 1
  cysteine and glycine rich protein 2
  cytoplasmic polyadenylation element binding protein 4
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 13
  death inducer-obliterator 1
  defensin alpha 5
  DEK proto-oncogene
  DExD-box helicase 39B
  DGCR8 microprocessor complex subunit
  DIS3 like 3'-5' exoribonuclease 2
  DNA topoisomerase II alpha
  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  double PHD fingers 2
  drebrin 1
  drosha ribonuclease III
  dual specificity phosphatase 11
  dual specificity phosphatase 14
  dynein cytoplasmic 1 heavy chain 1
  dynein light chain LC8-type 1
  dyskerin pseudouridine synthase 1
  E1A binding protein p300
  E2F transcription factor 6
  early endosome antigen 1
  ecto-NOX disulfide-thiol exchanger 1
  ecto-NOX disulfide-thiol exchanger 2
  ELAV like RNA binding protein 1
  ELAV like RNA binding protein 2
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  enhancer of mRNA decapping 4
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  epithelial splicing regulatory protein 1
  ERH mRNA splicing and mitosis factor
  euchromatic histone lysine methyltransferase 1
  eukaryotic translation initiation factor 4A3
  EWS RNA binding protein 1
  family with sequence similarity 120A
  family with sequence similarity 98 member B
  fibrillarin
  FMR1 autosomal homolog 1
  FMR1 autosomal homolog 2
  forkhead box S1
  FUS RNA binding protein
  G3BP stress granule assembly factor 1
  G3BP stress granule assembly factor 2
  GATA binding protein 2
  GATA binding protein 3
  GCN1 activator of EIF2AK4
  gem nuclear organelle associated protein 2
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 5
  general transcription factor IIIC subunit 1
  glucosaminyl (N-acetyl) transferase 2 (I blood group)
  G-patch domain containing 8
  GRB10 interacting GYF protein 2
  H1.1 linker histone, cluster member
  H1.10 linker histone
  H2A clustered histone 18
  H2A clustered histone 20
  H2A clustered histone 4
  H2A.X variant histone
  H2B clustered histone 3
  H2B clustered histone 5
  H3 clustered histone 1
  H3.4 histone
  H4 histone 16
  HEAT repeat containing 1
  heat shock protein family A (Hsp70) member 1A
  heat shock transcription factor 2 binding protein
  helicase with zinc finger
  helicase with zinc finger 2
  hepatocyte nuclear factor 4 alpha
  heterochromatin protein 1 binding protein 3
  histone deacetylase 2
  IK cytokine
  inhibitor of growth family member 3
  inner membrane mitochondrial protein
  insulin like growth factor 1 receptor
  insulin like growth factor 2 mRNA binding protein 1
  integrator complex subunit 6
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  karyopherin subunit alpha 2
  karyopherin subunit beta 1
  kelch like family member 8
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 3
  kinectin 1
  kinesin family member 26B
  KRR1 small subunit processome component homolog
  lamin A/C
  lamin B2
  LAS1 like ribosome biogenesis factor
  leucine rich pentatricopeptide repeat containing
  leukocyte receptor cluster member 8
  ligand dependent nuclear receptor interacting factor 1
  LIM domain and actin binding 1
  LTV1 ribosome biogenesis factor
  LUC7 like 3 pre-mRNA splicing factor
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine demethylase 1B
  lysine demethylase 3A
  lysine demethylase 6A
  lysine methyltransferase 2A
  macroH2A.1 histone
  mago homolog, exon junction complex subunit
  mannosidase alpha class 1B member 1
  MAPK activated protein kinase 3
  mediator complex subunit 12
  metal response element binding transcription factor 2
  methyl-CpG binding domain protein 2
  methylphosphate capping enzyme
  mitochondrial rRNA methyltransferase 1
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase kinase 1
  MLLT1 super elongation complex subunit
  M-phase phosphoprotein 8
  MRT4 homolog, ribosome maturation factor
  Mtr4 exosome RNA helicase
  mucin 1, cell surface associated
  musashi RNA binding protein 2
  muscleblind like splicing regulator 2
  MYB binding protein 1a
  myelin expression factor 2
  N-acetyltransferase 10
  NDUFA4 mitochondrial complex associated
  NFKB repressing factor
  NHP2 ribonucleoprotein
  nibrin
  NME/NM23 nucleoside diphosphate kinase 1
  NME/NM23 nucleoside diphosphate kinase 4
  NOP10 ribonucleoprotein
  NOP14 nucleolar protein
  NOP58 ribonucleoprotein
  NPR2 like, GATOR1 complex subunit
  NPR3 like, GATOR1 complex subunit
  nuclear cap binding protein subunit 1
  nuclear cap binding protein subunit 2
  nuclear cap binding subunit 3
  nuclear FMR1 interacting protein 2
  nuclear mitotic apparatus protein 1
  nuclear receptor binding SET domain protein 1
  nuclear receptor coactivator 5
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nucleolar protein 6
  nucleolar protein 9
  nucleolin
  nucleoporin 93
  nudE neurodevelopment protein 1 like 1
  nudix hydrolase 16 like 1
  O-linked N-acetylglucosamine (GlcNAc) transferase
  paraspeckle component 1
  PAX3 and PAX7 binding protein 1
  PDZ and LIM domain 5
  pentatricopeptide repeat domain 3
  peptidylprolyl isomerase B
  peptidylprolyl isomerase E
  peptidylprolyl isomerase like 1
  periphilin 1
  peroxiredoxin 4
  PEST proteolytic signal containing nuclear protein
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD finger protein 3
  PHD finger protein 5A
  PHD finger protein 6
  phosphatase and tensin homolog
  phosphoglycerate dehydrogenase
  plakophilin 1
  plakophilin 2
  plectin
  pleiotrophin
  pleiotropic regulator 1
  poly(A) binding protein cytoplasmic 4
  poly(A) binding protein interacting protein 1
  poly(A) binding protein nuclear 1
  polycomb group ring finger 1
  polycomb group ring finger 2
  polycomb group ring finger 3
  polycomb group ring finger 6
  polyhomeotic homolog 1
  polyhomeotic homolog 2
  polyhomeotic homolog 3
  polypyrimidine tract binding protein 1
  polypyrimidine tract binding protein 3
  POTE ankyrin domain family member E
  progesterone receptor
  programmed cell death 11
  proline rich coiled-coil 2A
  prolyl 4-hydroxylase subunit beta
  proteasome 20S subunit beta 5
  protein activator of interferon induced protein kinase EIF2AK2
  protein arginine methyltransferase 6
  protein kinase, DNA-activated, catalytic subunit
  pumilio RNA binding family member 1
  pumilio RNA binding family member 2
  purine rich element binding protein A
  purine rich element binding protein B
  pyrroline-5-carboxylate reductase 1
  RAB1A, member RAS oncogene family
  RALY heterogeneous nuclear ribonucleoprotein
  RAN binding protein 2
  receptor for activated C kinase 1
  replication initiator 1
  reticulocalbin 1
  ribonucleotide reductase catalytic subunit M1
  ribophorin I
  ribosomal protein L35
  ribosomal protein L7
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S3
  ribosomal RNA processing 12 homolog
  ring finger protein 1
  ring finger protein 1
  ring finger protein 114
  ring finger protein 144A
  ring finger protein 2
  RING1 and YY1 binding protein
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding fox-1 homolog 2
  RNA binding motif protein 14
  RNA binding protein with serine rich domain 1
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 2
  ryanodine receptor 3
  SAFB like transcription modulator
  scaffold attachment factor B2
  Scm polycomb group protein homolog 1
  Scm polycomb group protein like 1
  Scm polycomb group protein like 2
  SEC23 homolog B, COPII coat complex component
  SEC23 interacting protein
  SEC24 homolog B, COPII coat complex component
  SEC31 homolog A, COPII coat complex component
  SEC31 homolog B, COPII coat complex component
  secretion associated Ras related GTPase 1A
  serine/threonine kinase receptor associated protein
  serpin family B member 12
  serrate, RNA effector molecule
  sideroflexin 1
  signal recognition particle 14
  signal recognition particle 9
  signal sequence receptor subunit 4
  Sin3A associated protein 18
  small nuclear ribonucleoprotein 13
  small RNA binding exonuclease protection factor La
  SMU1 DNA replication regulator and spliceosomal factor
  SNW domain containing 1
  solute carrier family 25 member 10
  solute carrier family 25 member 11
  solute carrier family 39 member 7
  SON DNA and RNA binding protein
  speckle type BTB/POZ protein
  spectrin repeat containing nuclear envelope protein 1
  spen family transcriptional repressor
  spermatid perinuclear RNA binding protein
  spliceosome associated factor 3, U4/U6 recycling protein
  SPT16 homolog, facilitates chromatin remodeling subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  SR-related CTD associated factor 11
  SRSF protein kinase 2
  SRY-box transcription factor 2
  SS18L1 subunit of BAF chromatin remodeling complex
  staufen double-stranded RNA binding protein 1
  staufen double-stranded RNA binding protein 2
  suppressor of cytokine signaling 2
  surfactant protein C
  SURP and G-patch domain containing 1
  SURP and G-patch domain containing 2
  survival of motor neuron 1, telomeric
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  TBL1X receptor 1
  telomeric repeat binding factor 2
  thyroid hormone receptor associated protein 3
  TIA1 cytotoxic granule associated RNA binding protein
  TIA1 cytotoxic granule associated RNA binding protein like 1
  TNF receptor associated factor 4
  trafficking protein particle complex 12
  trafficking protein particle complex 13
  transcription activation suppressor
  transformer 2 alpha homolog
  transglutaminase 1
  translocase of inner mitochondrial membrane 50
  transmembrane protein 41B
  trinucleotide repeat containing adaptor 6B
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  tripartite motif containing 37
  TSC complex subunit 2
  Tu translation elongation factor, mitochondrial
  tudor domain containing 1
  tuftelin interacting protein 11
  tumor protein p53
  tumor suppressor candidate 3
  twinkle mtDNA helicase
  tyrosyl-tRNA synthetase 2
  ubiquitin associated protein 2 like
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 J1
  ubiquitin like 5
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 22
  ubiquitin specific peptidase 7
  UPF1 RNA helicase and ATPase
  UTP20 small subunit processome component
  vir like m6A methyltransferase associated
  VPS11 core subunit of CORVET and HOPS complexes
  WD repeat domain 12
  WD repeat domain 33
  WD repeat domain 5
  whirlin
  WW domain binding protein 11
  X-ray repair cross complementing 5
  Y-box binding protein 1
  Y-box binding protein 3
  YLP motif containing 1
  YTH domain containing 1
  YTH N6-methyladenosine RNA binding protein 1
  YTH N6-methyladenosine RNA binding protein 2
  YTH N6-methyladenosine RNA binding protein 3
  YY1 associated factor 2
  YY1 transcription factor
  zinc finger and BTB domain containing 16
  zinc finger CCCH-type containing 11A
  zinc finger CCCH-type containing 13
  zinc finger CCCH-type containing 4
  zinc finger CCCH-type containing 7A
  zinc finger CCCH-type containing, antiviral 1
  zinc finger CCCH-type containing, antiviral 1 like
  zinc finger CCHC-type containing 3
  zinc finger CCHC-type containing 8
  zinc finger DHHC-type palmitoyltransferase 18
  zinc finger DHHC-type palmitoyltransferase 23
  zinc finger protein 326
  zinc finger protein 385B
  zinc finger protein 638
  zinc finger protein 687
  zinc finger protein 740
  zinc finger protein 787
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.