ARAF, A-Raf proto-oncogene, serine/threonine kinase

ARAF, A-Raf proto-oncogene, serine/threonine kinase

• This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

• Gene Synonyms (serine/threonine-protein kinase A-Raf, A-Raf proto-oncogene serine/threonine-protein kinase, Oncogene ARAF1, Ras-binding protein DA-Raf, proto-oncogene A-Raf-1, proto-oncogene Pks, v-raf murine sarcoma 3611 viral oncogene homolog 1, v-raf murine sarcoma 3611 viral oncogene-like protein, A-RAF, ARAF1, PKS2, RAFA1,)
• NCBI Gene ID: 369
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96II5
  UNIPROT ID#>>A0A024R178
  UNIPROT ID#>>P10398
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

A-Raf proto-oncogene, serine/threonine kinase interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  A-kinase anchoring protein 8
  Aly/REF export factor
  angiotensin II receptor associated protein
  apoptosis inducing factor mitochondria associated 1
  A-Raf proto-oncogene, serine/threonine kinase
  argininosuccinate synthase 1
  ATP synthase F1 subunit beta
  ATP synthase membrane subunit DAPIT
  autophagy related 16 like 1
  BAG cochaperone 2
  BCL2 associated agonist of cell death
  beclin 1
  B-Raf proto-oncogene, serine/threonine kinase
  BUB1, mitotic checkpoint serine/threonine kinase
  calumenin
  carbamoyl-phosphate synthase 1
  carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  casein kinase 2 beta
  catenin alpha 1
  cell division cycle 37
  cell division cycle 37, HSP90 cochaperone
  chibby family member 1, beta catenin antagonist
  chromodomain helicase DNA binding protein 6
  chromosome 1 open reading frame 35
  coiled-coil domain containing 22
  coiled-coil-helix-coiled-coil-helix domain containing 4
  COP9 signalosome subunit 3
  COPI coat complex subunit alpha
  CTD phosphatase subunit 1
  cyclin D2
  cyclin dependent kinase 1
  cyclin dependent kinase 4
  cyclin dependent kinase 6
  cyclin dependent kinase 9
  cyclin dependent kinase inhibitor 2B
  DEAD-box helicase 17
  DEAD-box helicase 5
  death inducer-obliterator 1
  dermcidin
  desmoplakin
  DExH-box helicase 9
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member A1
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member B6
  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  dual specificity phosphatase 7
  dynein cytoplasmic 1 intermediate chain 2
  dynein light chain LC8-type 1
  E2F transcription factor 6
  EGF containing fibulin extracellular matrix protein 1
  egl-9 family hypoxia inducible factor 3
  ELAV like RNA binding protein 1
  elongin B
  elongin C
  emerin
  enolase 1
  EPH receptor A2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 epsilon 1
  eukaryotic translation elongation factor 1 gamma
  eukaryotic translation elongation factor 2
  EWS RNA binding protein 1
  exportin 1
  exportin for tRNA
  Fas associated factor family member 2
  F-box protein 6
  ferrochelatase
  fibrillarin
  fibroblast growth factor receptor 4
  FKBP prolyl isomerase 4
  FKBP prolyl isomerase 5
  FKBP prolyl isomerase 8
  FUS RNA binding protein
  G protein subunit alpha 12
  galectin 3 binding protein
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 6
  GLIS family zinc finger 2
  glutamate dehydrogenase 1
  glutaminyl-peptide cyclotransferase
  glutamyl-prolyl-tRNA synthetase 1
  GNAS complex locus
  H1.2 linker histone, cluster member
  H2A clustered histone 12
  H2B clustered histone 12
  H4 clustered histone 1
  HCLS1 associated protein X-1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 6
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein U
  high mobility group nucleosomal binding domain 2
  HIV-1 Tat specific factor 1
  homeodomain interacting protein kinase 4
  hornerin
  HRas proto-oncogene, GTPase
  importin 7
  importin 8
  importin 9
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 2
  insulin receptor substrate 4
  interferon regulatory factor 7
  interleukin 1 receptor associated kinase 1
  interleukin 1 receptor associated kinase 2
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  itchy E3 ubiquitin protein ligase
  Janus kinase 3
  junction plakoglobin
  karyopherin subunit beta 1
  kelch like family member 12
  keratin 1
  keratin 10
  keratin 16
  keratin 2
  keratin 5
  keratin 9
  kinesin family binding protein
  KRAS proto-oncogene, GTPase
  large tumor suppressor kinase 2
  leucine rich repeat containing 59
  leucyl-tRNA synthetase 1
  MAD2 mitotic arrest deficient-like 1
  matrix AAA peptidase interacting protein 1
  methionyl-tRNA synthetase 1
  mitochondrial rRNA methyltransferase 3
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase 2
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase 5
  mitotic arrest deficient 2 like 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  mutL homolog 1
  MYC proto-oncogene, bHLH transcription factor
  myosin XVIIIA
  NADH:ubiquinone oxidoreductase core subunit S3
  Nanog homeobox
  negative elongation factor complex member C/D
  neurofibromin 2
  NIMA related kinase 1
  NME/NM23 nucleoside diphosphate kinase 1
  NME/NM23 nucleoside diphosphate kinase 2
  NRAS proto-oncogene, GTPase
  nucleolin
  nucleophosmin 1
  nucleoside-triphosphatase, cancer-related
  nudix hydrolase 14
  PDZ and LIM domain 5
  PDZ binding kinase
  peroxiredoxin 1
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphofructokinase, platelet
  phosphoglycerate dehydrogenase
  phosphoinositide-3-kinase regulatory subunit 1
  platelet derived growth factor receptor beta
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  pre-mRNA processing factor 6
  progesterone receptor membrane component 1
  prolyl 3-hydroxylase 1
  prolyl 4-hydroxylase subunit alpha 2
  prolyl 4-hydroxylase subunit beta
  prostaglandin E synthase 3
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 6
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 6 catalytic subunit
  PTEN induced kinase 1
  pyruvate kinase M1/2
  Rab geranylgeranyltransferase subunit beta
  RAB3A interacting protein
  RAN, member RAS oncogene family
  Ras association domain family member 1
  RAS related
  RAS related 2
  RB binding protein 7, chromatin remodeling factor
  receptor for activated C kinase 1
  receptor interacting serine/threonine kinase 4
  regulator of G protein signaling 12
  reticulocalbin 1
  reticulocalbin 2
  ribophorin II
  ribosomal protein L10
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13
  ribosomal protein L17
  ribosomal protein L21
  ribosomal protein L22
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L28
  ribosomal protein L29
  ribosomal protein L34
  ribosomal protein L37
  ribosomal protein L39
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S11
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S15a
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S25
  ribosomal protein S27 like
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S6
  ribosomal protein S6 kinase A1
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ring finger protein 2
  RNA binding motif protein 14
  RNA binding motif protein 25
  RuvB like AAA ATPase 1
  serine/threonine kinase 11
  signal sequence receptor subunit 1
  solute carrier family 25 member 1
  solute carrier family 25 member 13
  solute carrier family 25 member 22
  splicing factor 3a subunit 2
  STIP1 homology and U-box containing protein 1
  stratifin
  stromal cell derived factor 4
  suppressor of cytokine signaling 6
  TATA-box binding protein associated factor 15
  t-complex 1
  testin LIM domain protein
  testis associated actin remodelling kinase 1
  thyroid hormone receptor interactor 6
  TIR domain containing adaptor protein
  TRAF-type zinc finger domain containing 1
  trans-2,3-enoyl-CoA reductase
  translocase of inner mitochondrial membrane 44
  translocase of inner mitochondrial membrane 50
  tripartite motif containing 21
  tripartite motif containing 28
  TSC complex subunit 1
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1a
  tubulin alpha 4a
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 1
  ubiquitin A-52 residue ribosomal protein fusion product 1
  UBX domain protein 6
  WNK lysine deficient protein kinase 1
  X-ray repair cross complementing 5
  Y-box binding protein 1
  Y-box binding protein 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.