APBB2, amyloid beta precursor protein binding family B member 2

APBB2, amyloid beta precursor protein binding family B member 2

• The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Gene Synonyms (amyloid-beta A4 precursor protein-binding family B member 2, Fe65-like 1, protein Fe65-like 1, FE65L, FE65L1,)
• NCBI Gene ID: 323
• Species: Homo sapiens (Human)
• UNIPROT ID#>>G5E9Y1
  UNIPROT ID#>>B4E2F2
  UNIPROT ID#>>Q92870
  UNIPROT ID#>>B4DJ88
  UNIPROT ID#>>Q5I0G1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

amyloid beta precursor protein binding family B member 2 interacts with:

• A-kinase anchoring protein 1
  amyloid beta precursor like protein 1
  amyloid beta precursor like protein 2
  amyloid beta precursor protein
  amyloid beta precursor protein binding family B member 2
  apolipoprotein L2
  ATPase copper transporting alpha
  cellular communication network factor 6
  COBW domain containing 1
  epidermal growth factor receptor
  formin 2
  gigaxonin
  golgi associated PDZ and coiled-coil motif containing
  heat shock protein family A (Hsp70) member 8
  heterogeneous nuclear ribonucleoprotein L
  HGF activator
  lactate dehydrogenase A like 6B
  lysosomal associated membrane protein 1
  mitochondrial ribosomal protein L1
  mitogen-activated protein kinase 8
  NCK adaptor protein 1
  nuclear factor kappa B subunit 1
  OTU deubiquitinase with linear linkage specificity like
  oxysterol binding protein like 2
  queuine tRNA-ribosyltransferase catalytic subunit 1
  Rap1 GTPase-GDP dissociation stimulator 1
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 1
  sortilin 1
  synapse defective Rho GTPase homolog 2
  synaptotagmin binding cytoplasmic RNA interacting protein
  TBC1 domain family member 2B
  TBC1 domain family member 4
  TNFRSF1A associated via death domain
  transmembrane protein 30B
  tubulin alpha 1a
  tumor protein p53
  vav guanine nucleotide exchange factor 1
  vir like m6A methyltransferase associated
  WD repeat domain 41
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.