APLP1, amyloid beta precursor like protein 1

APLP1, amyloid beta precursor like protein 1

• This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (amyloid-like protein 1, amyloid beta (A4) precursor-like protein 1, amyloid precursor-like protein 1, APLP,)
• NCBI Gene ID: 333
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51693
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

amyloid beta precursor like protein 1 interacts with:

• amyloid beta (A4) precursor protein-binding, family B, member 1
  amyloid beta precursor protein binding family B member 3
  arrestin beta 1
  casein kinase 2 beta
  cyclin dependent kinase 4
  cyclin dependent kinase inhibitor 1A
  cyclin dependent kinase inhibitor 2C
  cysteine rich C-terminal 1
  DAB adaptor protein 1
  DAB adaptor protein 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation initiation factor 2 subunit beta
  glucagon like peptide 1 receptor
  glutamate ionotropic receptor NMDA type subunit 1
  glutamate ionotropic receptor NMDA type subunit 2A
  glutamate ionotropic receptor NMDA type subunit 2B
  glutathione S-transferase mu 4
  growth differentiation factor 9
  heat shock protein family E (Hsp10) member 1
  huntingtin associated protein 1
  inhibitor of growth family member 5
  ligand dependent nuclear receptor interacting factor 1
  lysine acetyltransferase 5
  major histocompatibility complex, class II, DQ alpha 1
  M-phase phosphoprotein 6
  nascent polypeptide associated complex subunit alpha
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  PHD finger protein 10
  prion protein
  protocadherin alpha 4
  purine nucleoside phosphorylase
  RAP1B, member of RAS oncogene family
  regulator of chromosome condensation 1
  RNA binding motif protein 48
  SET domain bifurcated histone lysine methyltransferase 1
  spermidine/spermine N1-acetyltransferase 1
  survival of motor neuron 1, telomeric
  syntaxin 5
  synuclein alpha
  target of EGR1, exonuclease
  thymidine kinase 1
  thymosin beta 4 X-linked
  thymosin, beta 4, X chromosome
  transcription factor 21
  TSC22 domain family member 1
  UTP14A small subunit processome component
  vimentin
  zinc finger protein 24

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.